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KMID : 1145520160020020096
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Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 2 p.96 ~ p.102
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Comparative study of linear and cyclic forms of apoptosis-targeting peptide
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Ha Yeong-Su
Soni Nisarg
Huynh Phuong Tu
Lee Byung-Heon
An Gwang-Il
Yoo Jeong-Soo
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Abstract
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Apoptosis, a genetically determined process of programmed cell death, is considered a vital component of various processes including normal cell turnover, animal development, and tissue homeostasis. It has a crucial role in many medical disorders and hence the development of non-invasive imaging tool is highly demanded. Recently, we have developed a peptide-based radioactive probe (ApoPep-1) for apoptosis detection. In that work the potential of probe for apoptosis detection was verified, however in vivo stability of radiolabeled peptide was not enough to monitor apoptosis for extended period. In current study, we prepared cyclic ApoPep-1 peptides to improve the stability of origianl linear ApoPep-1 and carried out direct comparison studies in vitro and in vivo. A targeting efficacy of newly synthesized cyclic ApoPep-1 peptide for apoptosis was confirmed in acute myocardial infarct model.
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KEYWORD
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ApoPep-1 peptide, Apoptosis, Cyclic peptide, Proteolytic stability, Radiopharmaceuticals
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